A microscopic framework that combines the Hartree-Fock-Bogoliubov (HFB) approach with the fusion by diffusion (FBD) model is proposed to investigate the synthesis mechanism of superheavy nuclei (SHN). For the reaction , the calculated evaporation-residue cross section (ERCS) reproduces the experimental data reasonably well. The method enables self-consistent extraction of the fusion injection point and inner barrier from HFB potential-energy surfaces (PES), thereby incorporating nuclear structure effects while eliminating phenomenological tuning at the fusion stage. For cold-fusion reactions, the PES features a hyperasymmetric valley driven by shell effects. This Pb anchored valley connects the entrance channel to compound nucleus formation and provides an exit channel for cluster decay. We further investigate the cold-fusion reactions and , obtaining a near-exponential decrease of with compound-nucleus charge , consistent with established systematics. This approach demonstrates a self-consistent framework that can reduce uncertainties in the fusion stage of SHN production.

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