We develop a quantum spin-density-matrix framework for heavy-quark spin dynamics in relativistic heavy-ion collisions. Starting from an initial polarization induced along the magnetic-field direction, we derive the evolution equation for spin polarization within this framework and obtain analytic solutions. The evolved polarization is connected to open heavy-flavor observables via a fragmentation-based hadronization prescription. For vector mesons, the spin-alignment parameter is constructed by coupling the heavy-quark spin to that of the light antiquark produced during fragmentation. We confront our results with recent ALICE measurements of prompt spin alignment in Pb–Pb collisions at and extract an effective depolarization strength that determines the spin-relaxation time scale. Using this fitted parameter, we provide benchmark estimates for and polarization, up to an overall spin-transfer normalization. We further estimate the recently proposed elliptic polarization harmonic arising from path-length-dependent depolarization in an anisotropic fireball.

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