This work presents the first dedicated optical–mid-infrared time-domain variability and dust-reverberation analysis of the isolated NLSy1 galaxies Mrk 42 and Mrk 493. We combine ZTF optical light curves, WISE mid-infrared monitoring, archival Swift and SDSS data, and high-cadence IAC80 optical observations. Using colour–magnitude relations, flux–flux analysis, and interpolated cross-correlation functions, we trace variable optical continuum and delayed dust response. Both galaxies show positive optical–MIR lags consistent with dust reverberation. For Mrk 493, we measure an observed-frame g–W1 lag of d, corresponding to pc. For Mrk 42, the corresponding lag is d, giving pc. These lags provide optical–MIR dust-reverberation radii and BLR–dust scale comparisons for both objects; the resulting ratios are for Mrk 493 and –7 for Mrk 42. For Mrk 42, we derive the first host-subtracted AGN continuum luminosity at 5100 Å from SDSS spectral decomposition, giving a self-consistent BLR–dust comparison on an AGN-only luminosity basis. Both galaxies have similar radial hierarchies but different colour behaviour: Mrk 493 shows significant optical and MIR bluer-when-brighter trends, whereas Mrk 42 shows strong optical but weak MIR colour variability. We also identify and analyse a major optical flare in Mrk 42 with four internal maxima spaced by 45–47 d. We interpret this signal as quasi-periodic substructure within a broader accretion-driven flare, rather than as a strictly coherent periodic process. These results indicate that, even in dynamically isolated environments, the variability of low-mass, high-accretion-rate AGNs is governed mainly by the intrinsic state of the accretion flow and its coupling to circumnuclear dust.

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