The Minkowski mixed volume of subpolytopes of a polytope clearly does not exceed the normalized volume . Equality holds if and only if the subpolytopes are interlaced, i.e., each proper face intersects at least of the polytopes . Efficiently computing mixed volumes for more general collections of subpolytopes is crucial for estimating the complexity of numerically solving polynomial systems. Motivated by relaxing the bound to , we prove a combinatorial formula for the mixed volume of a broad class of semi-interlaced polytopes. This class includes, in particular, the off-coordinate polytopes used in computing algebraic degrees – such as Maximum Likelihood, Euclidean Distance, and Polar degrees – via the Kouchnirenko–Bernshtein theory. We also present applications of our results to the Arnold monotonicity problem (1982-16), which concerns the dependence of Milnor numbers on the Newton polyhedra.

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