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We study the higher-order fractional Schrödinger equation with local nonlinear perturbations and investigate both the forward and inverse problems. We establish both the Sobolev and Hölder estimates for the well-posedness of the nonlinear problem, based on the corresponding estimates derived for the linear fractional Schrödinger equation. For the inverse problem, we show that the local nonlinear perturbations can be uniquely determined from the Dirichlet-to-Neumann map, by using the higher-order linearization and the unique continuation property of the fractional Laplace operator.

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