Optical tweezers are a powerful tool for creating defect-free arrays of atoms and molecules, enabling advances in quantum simulation, computation, and precision metrology. However, the achievable array size is limited by the initial loading fraction, typically for atoms and for molecules. Here, we propose a general scheme for enabling multiple loading cycles by protecting trapped particles using a repulsive barrier. We show that collision-limited lifetimes of particles in protected tweezers can exceed one second, leading to filling fractions of over after four loading cycles. Combined with existing rearrangement techniques, this approach enables efficient unity filling of tweezer arrays and provides a scalable pathway towards larger quantum technology platforms.

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