We study the defocusing energy-critical inhomogeneous nonlinear Schrödinger equation with initial data , where and . We prove global well-posedness and scattering for arbitrary non-radial data. The main difficulties are that, when , the derivative of the critical nonlinearity is only Hölder continuous, so the short-time perturbation argument cannot be closed in , and that the singular coefficient breaks translation symmetry. To handle these issues, we exploit the weak-space structure , introduce exotic Strichartz norms, and prove a long-time stability theorem for the general energy-critical inhomogeneous nonlinear Schrödinger equation. We also show that profiles escaping to spatial infinity are asymptotically linear because of the decay of . Consequently, almost periodic solutions are compact modulo scaling only, with neither spatial nor frequency center parameters. Combined with the concentration–compactness argument of Kenig–Merle [\emph{Invent. Math.} (2006), 645–675], this yields the main theorem.

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