We investigate the discovery prospects of a singly produced vector-like bottom quark in the Type-II Two-Higgs-Doublet Model extended by an vector-like doublet. We focus on the non-standard decay chain , followed by , where or , leading to a final state with one charged lepton, missing transverse energy, and multiple -jets. We perform a full simulation of both signal and Standard Model backgrounds at TeV. We show that the exotic channels can dominate over the conventional decay modes, reaching branching ratios of order for both neutral scalars in the alignment limit. A conventional cut-based analysis provides a discovery significance only at sufficiently high integrated luminosity. By contrast, an XGBoost-based multivariate analysis substantially improves the signal-background discrimination and extends the discovery reach up to TeV with and up to TeV with , even in the presence of systematic uncertainties as large as .

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