We present a microscopic calculation of two particle-two hole meson exchange current response functions in asymmetric nuclei, with particular emphasis on the Ar nucleus. Employing a relativistic mean-field and relativistic Fermi gas framework, we compute the nuclear response for Ar and compare it with that of the symmetric Ca nucleus, analyzing the role of proton-neutron imbalance. The model incorporates distinct proton and neutron Fermi momenta to accurately capture the nuclear dynamics of systems with . Our results indicate that using Ca as a proxy for Ar leads to a systematic error of approximately 10%. Additionally, we propose an asymmetric scaling formula to obtain the 2p2h response for arbitrary nuclei from the C response, improving the description of asymmetric nuclei. Finally, we benchmark our predictions against inclusive electron scattering and neutrino cross sections.

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