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This paper presents new lower bounds for the first general Zagreb index involving two, three, and four arbitrary degrees of vertices of a simple graph . For the special cases and , the results give sharper bounds for the first Zagreb index and the modified first Zagreb index , thereby improving several well-known inequalities in the literature. Furthermore, some applications of the derived bounds for are demonstrated, establishing new bounds for the second Zagreb index, the spectral radius, Nordhaus-Gaddum type bounds, and their corresponding coindices.

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