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This paper focus on the symmetry and symmetry breaking about the second order Hydrogen Uncertainty Principle. \emph{Firstly}, by choosing a suitable test function, we give a negative answer to the conjecture presented by Cazacu, Flynn and Lam in [\emph{J. Funct. Anal.} (2022), Paper No. 109659, 37 pp] for , and emphasizing the symmetry breaking phenomenon. \emph{Secondly}, we obtain a family of sharp weighted second order Hydrogen Uncertainty Principle, and prove the extremal functions are radial, which extends the work of Duong and Nguyen [The sharp second order Caffareli-Kohn-Nirenberg inequality and stability estimates for the sharp second order uncertainty principle, arXiv:2102.01425].

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