We investigate the forward–backward asymmetry in the production and elliptic flow of prompt D0 mesons in proton–lead (p–Pb) collisions at TeV using the heavy-flavor improved string-melting version of the AMPT model. The model calculations provide a simultaneous description of nuclear modification factor and in forward and backward rapidities. We find that the observed asymmetry arises from the interplay of initial-state cold nuclear matter effects and final-state partonic interactions, with the competition between coalescence and fragmentation playing a critical role in shaping the transverse momentum and rapidity dependence of both observables. This work suggests that a partonic medium is formed in high-multiplicity p-Pb collisions at LHC energies.

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