We consider the relationships between the domination number of graph, denoted , and the distance- domination number, denoted , and three parameters that lie between them: the packing number, denoted , the lower packing number, denoted , and the isolation number, denoted . There has been recent attention on the question of whether is bounded or unbounded for various families of graphs. We consider similar questions for the ratios of the five parameters. In particular we show that, while is unbounded in trees, it holds that is less than for all trees. Further, is at most in interval graphs, at most~ in permutation graphs, and at most in general asteroidal-triple-free graphs. We also show that every tree has a set of vertices that is both isolating and a packing, and characterize trees where .

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