We investigate the global well-posedness of a class of generalized Hillen–Painter systems – specifically, supercritical volume-filling chemotaxis models – in under the influence of Couette flow. It is well established that, in the absence of fluid flow, solutions to this system may develop finite-time singularities (blow-up) for arbitrary initial cell mass. It is proved that the introduction of a Couette flow with sufficiently large amplitude guarantees the global existence of solutions for all initial masses. By employing a novel frequency decomposition technique, we successfully remove the mass threshold limitation presented in previous studies on the domain (Wang et al., Commun. Contemp. Math.), thereby establishing global regularity in the whole space without any smallness assumptions.

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