The asymmetric simple exclusion process (ASEP) is an important particle model with deep connections to orthogonal polynomials. Motivated by this connection, Corteel and Williams introduced the Koornwinder moments at , which generalize the moments of Askey–Wilson polynomials. They showed that the partition function of the two-species ASEP is equal to for a one-row partition . In this paper, we investigate a conjecture of Rains on the positivity of the minimal numerator of the Koornwinder moment . We derive the first explicit formula for this moment, thereby obtaining a precise formulation of the conjecture by determining the minimal denominator of . We also propose a generalization of the conjecture for the more general Koornwinder moments indexed by two partitions at special parameter values. We prove the generalized Rains’ conjecture in two special cases: and . For , we construct a lattice path model and obtain a combinatorial formula for in terms of non-intersecting lattice paths. For , we establish an explicit product formula for and give a combinatorial interpretation using lecture hall tableaux.

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