In this paper we consider solutions of the three-dimensional Navier-Stokes system and investigate sharpness of the a priori bound \begin{align*} \frac{d}{dt}|\boldsymbol{u}|_q^q \leq C|\boldsymbol{u}|_q^{q\frac{q-1}{q-3}}, \qquad q > 3. \end{align*} This bound is closely related to the Ladyzhenskaya-Prodi-Serrin conditions characterizing classical solutions of the Navier-Stokes system. Velocity fields maximizing the rate of growth under certain constraints are found as solutions of a suitable optimization problem which is solved numerically using a Riemannian conjugate gradient approach. The results obtained for different and increasing values of indicate that the bound is indeed sharp, up to a numerical prefactor, and therefore cannot be fundamentally improved. Additionally, the results also suggest that the rate of growth diverges as .

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