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The Casimir effect is typically governed by intrinsic material properties and lacks in situ tunability. We show that, in mesoscopic rings, both the magnitude and sign of the fermion-mediated Casimir interaction can be controlled via the Aharonov-Bohm effect. The resulting interplay between the Aharonov-Bohm phase and the Casimir interaction provides a route to engineer long-range interactions. In particular, this mechanism enables the implementation of non-Clifford SWAP gates between spatially separated spin qubits, thereby reducing the overhead for universal quantum computation and quantum error correction in spin-qubit architectures.

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