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We obtain a nigh optimal estimate for the first eigenvalue of two natural weighted problems associated to the bilaplacian (and of a continuous family of fourth-order elliptic operators in dimension ) in degenerating annuli (that are central objects in bubble tree analysis) in all dimension. The estimate depends only on the conformal class of the annulus. We also show that in dimension and dimension , the first eigenfunction (of the first problem) is never radial provided that the conformal class of the annulus is large enough. The other result is a weighted Poincaré-type inequality in annuli for those fourth-order operators. Applications to Morse theory are given.

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