For and , we first show a non-degenerate result of the extremal functions for the following Rellich-Sobolev type inequality \begin{align*} \int_{^N}|Δu|^2 x -C_{μ,1}\int_{^N}\frac{|\nabla u|^2}{|x|^2} x +C_{μ,2}\int_{^N}\frac{u^2}{|x|^4} x \geq μ\left(\int{^N}|u|^{\frac{2N}{N-4}} x\right)^\frac{N-4}{N},\quad \forall u\in C^\infty_0(^N), \end{align*} where , and are constants depending on and , which is a key ingredient in analyzing the blow-up phenomena of solutions to various elliptic equations on bounded or unbounded domains. Then by using spectral analysis combined with a compactness argument, we consider the stability of this inequality. Furthermore, we derive a remainder term inequality in the weak Lebesgue-norm sense in a subdomain with finite Lebesgue measure.

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