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In this article, we study the existence of normalized ground state solutions for the following biharmonic nonlinear Schrödinger equation with combined nonlinearities \begin{equation*} Δ^2u=λu+μ|u|^{q-2}u+|u|^{p-2}u,\quad \text {in } \end{equation*} having prescribed mass \begin{equation*} \int_{^N}|u|^2dx=a^2, \end{equation*} where , , , if , if , and is the Sobolev critical exponent and appears as a Lagrange multiplier. By using the Sobolev subcritical approximation method, we prove the second critical point of mountain pass type for the case , , , and . Moreover, we also consider the case and .

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