Comment on "Simulations of ionization equilibria in weak polyelectrolyte solutions and gels" by J. Landsgesell, L. Nová, O. Rud, F. Uhlík, D. Sean, P. Hebbeker, C. Holm and P. Ko\v sovan, Soft Matter, 2019,15, 1155-1185

In a recent review~Landsgesell et al., Soft Matter {\bf 15}, 1155 (2019) stated that $\text{pH}-{\text{pK}}_a$ is a ``universal parameter" for titrating systems. We show that this is not the case. This broken symmetry has important implications for constant pH (cpH) simulations. In particular, we show that for concentrated suspensions the error resulting from the use of cpH algorithm described by Landsgesell et al. is very significant, even for suspension containing 1:1 electrolyte. We show how to modify the cpH algorithm to account for the grand-canonical nature of the cpH simulations and for the charge neutrality requirement.