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Electric manipulation of skyrmions in 2D magnetic materials has garnered significant attention due to the potential in energy-efficient spintronic devices. In this work, using first-principles calculations and Monte Carlo simulations, we report the electric-field-tunable magnetic skyrmions in MnIn2Te4 monolayer. By adjusting the magnetic parameters, including the Heisenberg exchange interaction, DMI, and MAE, through applying an electric field, the formation or annihilation of skyrmions can be achieved. Our work suggests a platform for experimental realization of the electric-field-tunable magnetic skyrmions in 2D magnets.

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