The focus of our paper is to investigate the possibility of a minimizer for the Thomas-Fermi-Dirac-von Weizsäcker model on the lattice graph . The model is described by the following functional: \begin{equation*} E(\varphi)=\sum_{y\in^{3}}\left(|\nabla\varphi(y)|^2+ (\varphi(y))^{\frac{10}{3}}-(\varphi(y))^{\frac{8}{3}}\right)+ \sum_{x,y\in^{3}\atop ~\ y\neq x\hfill}\frac{{\varphi}^2(x){\varphi}^2(y)}{|x-y|}, \end{equation*} with the additional constraint that is sufficiently small. We also prove the nonexistence of a minimizer provided the mass is adequately large. Furthermore, we extend our analysis to a subset and prove the nonexistence of a minimizer for the following functional: \begin{equation*} E(Ω)=|\partialΩ|+\sum_{x,y\inΩ\atop ~y\neq x\hfill}\frac{1}{|x-y|}, \end{equation*} under the constraint that is sufficiently large.

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