Article Commentary on "Microdosimetric and radiobiological effects of gold nanoparticles at therapeutic radiation energies" [T.M. Gray et al., IJRB 2023, 99(2), 308-317]

In the recently published article by T.M. Gray et al. “Microdosimetric and radiobiological effects of gold nanoparticles at therapeutic radiation energies” (IJRB 2023, 99(2), 308-317) results of Monte Carlo simulations and radiobiological assays on the dosimetric effects of gold nanoparticles were presented. This commentary points out that the results of the two parts of the study are in contradiction and that the predicted magnitude of dose enhancement and its dependence on the shape of the nanoparticle appear implausible. Possible reasons for these observations are discussed.