We theoretically predict the squeezing-induced point-gap topology together with a {\it symmetry-protected skin effect} in a one-dimensional (1D) quadratic-bosonic system (QBS). Protected by a time-reversal symmetry, such a topology is associated with a novel invariant (similar to quantum spin-Hall insulators), which is fully capable of characterizing the occurrence of skin effect. Focusing on zero energy, the parameter regime of this skin effect in the phase diagram just corresponds to a {\it real-gap and point-gap coexisted topological phase}. Moreover, this phase associated with the {\it symmetry-protected skin effect} is experimentally observable by detecting the steady-state power spectral density. Our work is of fundamental interest in enriching non-Bloch topological physics by introducing quantum squeezing, and has potential applications for the engineering of symmetry-protected sensors based on the skin effect.

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