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The first measurement of the top quark pair () production cross section in proton-proton collisions at = 13.6 TeV is presented. Data recorded with the CMS detector at the CERN LHC in Summer 2022, corresponding to an integrated luminosity of 1.21 fb, are analyzed. Events are selected with one or two charged leptons (electrons or muons) and additional jets. A maximum likelihood fit is performed in event categories defined by the number and flavors of the leptons, the number of jets, and the number of jets identified as originating from b quarks. An inclusive production cross section of 881 23 (stat+syst) 20 (lumi) pb is measured, in agreement with the standard model prediction of 924 pb.

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