The relevance of the single-band two-dimensional Hubbard model to superconductivity in the doped cuprates has recently been questioned, based on Density matrix Renormalization Group (DMRG) computations on extended t-J models that found superconductivity over unrealistically broad doping region upon electron-doping, yet complete absence of superconductivity for hole-doping. We report very similar results from DMRG calculations on CuO two-leg ladder within the parent three-band correlated-electron Hamiltonian. The strong asymmetry found in our calculations are in contradiction to the deep and profound symmetry between electron- and hole-doped cuprate superconductors, apart from their critical temperatures, that has been found from recent experiments.

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