This paper concerns the non-degeneracy and uniqueness of ground states to the following nonlinear elliptic equation with mixed local and nonlocal operators, where , , , , denotes the fractional Laplacian, denotes the first Dirichlet eigenvalue of the operator in and denotes the unit ball in . We prove that the second eigenvalue to the linearized operator in the space of radially symmetric functions is simple, the corresponding eigenfunction changes sign precisely once in the radial direction, where is a ground state. By deriving a new Hopf type lemma, we then get that cannot be an eigenvalue of the linearized operator, which in turns leads to the non-degeneracy of ground states. Moreover, by establishing a Picone type identity with respect to antisymmetric functions, we then derive the non-degeneracy of ground states in the space of non-radially symmetric functions. Relying on the non-degeneracy of ground states and adapting a blow-up argument together with a continuation argument, we then obtain the uniqueness of ground states.

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