The results of this manuscript is the collection of my articles that I published during my PhD thesis. We show that there is an equivalence of categories between Lie-Rinehart algebras over a commutative algebra and homotopy equivalence classes of negatively graded acyclic Lie -algebroids. Therefore, this result makes sense of the universal Lie -algebroid of every singular foliation, without any additional assumption, and for Androulidakis-Zambon singular Lie algebroids. This extends to a purely algebraic setting the construction of the universal -manifold of a locally real analytic singular foliation of Lavau-C.L.-Strobl. Then we apply these results to study symmetries of singular foliations through universal Lie -algebroids. More precisely, we prove that a weak symmetry action of a Lie algebra on a singular foliation (which is morally an action of on the leaf space ) induces a unique up to homotopy Lie -morphism from to the Differential Graded Lie Algebra (DGLA) of vector fields on a universal Lie -algebroid of (such morphim is known under the name “-algebra action” in Mehta-Zambon. We deduce from this general result several geometrical consequences. For instance, We give an example of a Lie algebra action on an affine sub-variety which cannot be extended on the ambient space. Last, we present the notion of bi-submersion towers over a singular foliation and lift symmetries to those. \end{enumerate} \end{itemize}

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