In this work, we establish some abstract results on the perspective of the fractional Musielak-Sobolev spaces, such as: uniform convexity, Radon-Riesz property with respect to the modular function, -property, Brezis-Lieb type Lemma to the modular function and monotonicity results. Moreover, we apply the theory developed to study the existence of solutions to the following class of nonlocal problems \begin{equation*} \left{ \begin{array}{ll} (-Δ){Φ{x,y}}^s u = f(x,u),& \mbox{in }Ω, u=0,& \mbox{on }^N\setminus Ω, \end{array} \right. \end{equation*} where , is a bounded domain with Lipschitz boundary and is a Carathéodory function not necessarily satisfying the Ambrosetti-Rabinowitz condition. Such class of problems enables the presence of many particular operators, for instance, the fractional operator with variable exponent, double-phase and double-phase with variable exponent operators, anisotropic fractional -Laplacian, among others.

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