This paper aims to establish the existence of a weak solution for the following problem: \begin{equation*} (-Δ)^{s}{}u(x) +V(x)h(x,x,|u|)u(x)=\left(\int{^{N}}\dfrac{K(y)F(u(y))}{|x-y|^λ}dy \right) K(x)f(u(x)) \ \hbox{in} \ ^{N}, \end{equation*} where , is a generalized -function and is a generalized fractional Laplace operator. The functions , non-linear function are continuous and First, we introduce the homogeneous fractional Musielak-Sobolev space and investigate their properties. After that, we pose the given problem in that space. To establish our existence results, we prove and use the suitable version of Hardy-Littlewood-Sobolev inequality for Lebesque Musielak spaces together with variational technique based on the mountain pass theorem. We also prove the existence of a ground state solution by the method of Nehari manifold.

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