We study the fully degenerate second-order evolution equation ut=aij(t)uxixj+bi(t)uxi+c(t)u+f,t>0,x∈Rd given with the zero initial data. Here aij(t), bi(t), c(t) are merely locally integrable functions, and (aij(t))d×d is a nonnegative symmetric matrix with the smallest eigenvalue δ(t)≥0. We show that there is a positive constant N such that ∫0T(∫Rd(∣u∣+∣uxx∣)pdx)q/pe−q∫0tc(s)dsw(α(t))δ(t)dt≤N∫0T(∫Rd∣f(t,x)∣pdx)q/pe−q∫0tc(s)dsw(α(t))(δ(t))1−qdt, where p,q∈(1,∞), α(t)=∫0tδ(s)ds, and w is a Muckenhoupt’s weight.