We use the Leray spectral sequence for the sheaf cohomology groups with compact supports to obtain a vanishing result. The stalks of sheaves for the structure sheaf on the total space of a holomorphic fiber bundle has canonical topology structures. Using the standard \vCech argument we prove a density lemma for QDFS-topology on this stalks. In particular, we obtain a vanishing result for holomorphic fiber bundles with Stein fibers. Using Künnet formulas, properties of an inductive topology (with respect to the pair of spaces) on the stalks of the sheaf and a cohomological criterion for the Hartogs phenomenon we obtain the main result on the Hartogs phenomenon for the total space of holomorphic fiber bundles with (1,0)-compactifiable fibers.

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