We study the impact of lattice data on the determination of the strangeness asymmetry distribution in the general CTEQ-TEA global analysis of parton distribution functions (PDFs) of the proton. Firstly, we find that allowing a nonvanishing , at the initial ~GeV scale, in a global PDF analysis leads to a CT18As fit with similar quality to CT18A. Secondly, including the lattice data in the CT18As_Lat fit greatly reduces the -PDF error band size in the large- region. To further reduce its error would require more precise lattice data, extended to smaller values. We take ATLAS 7 TeV and production data, SIDIS di-muon production data, structure function data, E866 NuSea data, and E906 SeaQuest data as examples to illustrate the implication of CT18As and CT18As_Lat fits. The parametrization dependence for PDF ratio is analyzed with CT18As2 and CT18As2_Lat fits as results.

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