In this paper, we are devoted to studying the positive solutions of the following higher order Hardy-Hénon equation with an isolated singularity at the origin, where , is an integer and . For , singularity and decay estimates of solutions will be given. For with , we show the super polyharmonic properties of solutions near the singularity, which are essential tools in the study of polyharmonic equation. Using these properties, a classification of isolated singularities of positive solutions is established for the fourth order case, i.e., . Moreover, when , and with , we obtain the precise behavior of solutions near the singularity, i.e., either is a removable singularity or where is an exact constant.

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