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We explicitly test the asymptotic grand unification of a minimal 5-dimensional model with SO(10) gauge theory compactified on an orbifold. We consider all matter fields as propagating in the bulk and show that the gauge couplings asymptotically run to a fixed point in the UV. However, the Yukawa couplings will typically hit a Landau pole right above the compactification scale in this class of SO(10) models.

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