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We study production in high-energy nuclear collisions in a transport approach with dissociation and regeneration at finite temperatures. Due to the rare production in p+p collisions and the strong combination of uncorrelated and quarks in the quark-gluon plasma, the yield is significantly enhanced in the nuclear collisions at the Large Hadron Collider. Moreover, the centrality and momentum-dependent yield of sensitively reflect the thermalization degree of bottom quarks. And the newly observed experimental data favors a far from the thermal bottom quark distribution in the quark-gluon plasma.

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