This is a companion paper to earlier work of the authors, which proved an integral surgery formula for framed instanton homology. First, we present an enhancement of the large surgery formula, a rational surgery formula for null-homologous knots in any 3-manifold, and a formula encoding a large portion of . Second, we use the integral surgery formula to study the framed instanton homology of many 3-manifolds: Seifert fibered spaces with nonzero orbifold degrees, especially nontrivial circle bundles over any orientable surface, surgeries on a family of alternating knots and all twisted Whitehead doubles, and splicings with twist knots. Finally, we use the previous techniques and computations to study almost L-space knots, , the knots with for some . We show that an almost L-space knot of genus at least is fibered and strongly quasi-positive, and a genus-one almost L-space knot must be either the figure eight or the mirror of the knot in Rolfsen’s knot table.

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