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We study relation between Chiral Separation Effect (CSE) and Chiral Anomaly, and argue that CSE does not inherit the immutability of Chiral Anomaly. For QED in the leading order in electric charge, with point-splitting regularization in real-time formalism, we demontrate, in regularization-dependent way though, that CSE is an infrared (IR) effect, while the Anomaly is an ultra-violet (UV) phenomena. Thus, CSE in general is sensitive to non-perturbative interactions that alter the theory IR properties, while the Anomaly is fixed by Lorentz symmetry. The simplest example of such an interaction is the Yukawa-like fermion mass.

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