For any the symmetric decreasing rearrangement satisfies the Polya-Szegő inequality . The goal of this paper is to establish analogous results in the discrete setting for graphs satisfying suitable conditions. We prove that if the edge-isoperimetric problem on a graph has a sequence of nested minimizers, then this sequence gives rise to a rearrangement satisfying the Polya-Szegő inequality in . This shows, for example, that a specific rearrangement on the grid graph , going around the origin in a spiral-like manner, satisfies . The case is implied by an optimal ordering condition in vertex-isoperimetry. We use these ideas to prove that the canonical rearrangement on the infinite regular tree satisfies the Polya-Szegő inequality for all .

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