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Investigations of possible violations of the Pauli Exclusion Principle represent critical tests of the microscopic space-time structure and properties. Space-time non-commutativity provides a class of universality for several Quantum Gravity models. In this context the VIP-2 Lead experiment sets the strongest bounds, searching for Pauli Exclusion Principle violating atomic-transitions in lead, excluding the -Poincaré Non Commutative Quantum Gravity models far above the Planck scale for non-vanishing ``electric-like’’ components, and up to Planck scales if .

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