This paper studies the monic semi-classical Laguerre polynomials based on previous work by Boelen and Van Assche \cite{Boelen}, Filipuk et al. \cite{Filipuk} and Clarkson and Jordaan \cite{Clarkson}. Filipuk, Van Assche and Zhang proved that the diagonal recurrence coefficient satisfies the fourth Painlevé equation. In this paper we show that the off-diagonal recurrence coefficient fulfills the first member of Chazy II system. We also prove that the sub-leading coefficient of the monic semi-classical Laguerre polynomials satisfies both the continuous and discrete Jimbo-Miwa-Okamoto -form of Painlevé IV. By using Dyson’s Coulomb fluid approach together with the discrete system for and , we obtain the large asymptotic expansions of the recurrence coefficients and the sub-leading coefficient. The large asymptotics of the associate Hankel determinant (including the constant term) is derived from its integral representation in terms of the sub-leading coefficient.

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