The relation of HII galaxies (HIIGx) calibrated by a distance indicator is a reliable standard candle for measuring the Hubble constant . The most straightforward calibration technique anchors them with the first tier of distance ladders from the same galaxies. Recently another promising method that uses the cosmological model-independent Cosmic Chronometers (CC) as a calibrator has been proposed. We promote this technique by removing the assumptions about the cosmic flatness and using a non-parametric Artificial Neural Network for the data reconstruction process. We observe a correlation between the cosmic curvature density parameter and the slope of the relation, thereby improving the reliability of the calibration. Using the calibrated HIIGx Hubble diagram, we obtain a Type Ia Supernovae Hubble diagram free of the conventional assumption about . Finally we get a value of , which is compatible with latest Planck18 measurement.

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