We consider the Drell-Yan processes and at high- as probes of New Physics effects in semileptonic transitions. For this purpose, we describe the scattering amplitudes in terms of general form-factors which we match to the SMEFT at including corrections from dimension- operators and to tree-level mediators with (TeV) masses arising from ultraviolet models. By using the latest LHC run-II data from monolepton and dilepton production channels, we derive constraints on the SMEFT and on leptoquark models, with the most general flavor structures. Our results are compiled into the Mathematica package ‘HighPT’, which provides a simple way to perform high- collider analyses of Drell-Yan production Beyond the Standard Model.

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