Searches are presented for decays, where is a charmed meson and is a charged pion or kaon, using collision data collected by the LHCb experiment corresponding to an integrated luminosity of . The decays , and are observed for the first time. Their branching fractions, expressed as ratios relative to that of the decay, are determined to be \begin{align*} (B_c^+\to D^+ K^+π^-) =(1.96 \pm 0.23\pm 0.08 \pm 0.10)\times 10^{-3},&\ (B_c^+\to D^{+} K^+π^-) =(3.67 \pm 0.55 \pm 0.24\pm 0.20)\times 10^{-3},&\ (B_c^+\to D_s^+ K^+ K^-) =(1.61 \pm 0.35\pm 0.13\pm 0.07)\times 10^{-3}, \end{align} where the first uncertainty is statistical, the second is systematic, and the third is due to the limited precision on the -meson branching fractions. The decay channels proceed primarily through excited or resonances or mesons, and open a new avenue for studies of charge-parity violation in beauty mesons.

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