Based on Casas-Alvero conjecture [J. Algebra, 2001] we formulate the following conjecture.\ C*-algebraic Casas-Alvero Conjecture : Let A be a commutative C*-algebra, n∈N and let P(z)=(z−a1)(z−a2)⋯(z−an) be a polynomial over A with a1,a2,…,an∈A. If P shares a common zero with each of its (first) n−1 derivatives, then it is nth power of a linear monic C*-algebraic polynomial.\ We show that C*-algebraic Casas-Alvero Conjecture holds for C*-algebraic polynomials of degree 2.