We present quantitative results on the single-mass heavy-flavor contributions in the region of large virtualities up to three-loop order to the unpolarized structure function and the polarized structure function for the first time. These results are relevant for precision QCD analyses of the World deep-inelastic data and the data taken at future colliders, such as the Electron–Ion Collider, since the scaling violations due to massless and massive Wilson coefficients are significantly different. In order to measure the strong coupling constant and the twist-2 parton distribution functions consistently at highest precision, the next-to-next-to-leading order corrections have to be taken into account. Furthermore, the complete three-loop corrections will allow to reduce the present theory error of the charm mass as measured form deep-inelastic data. We provide a fast and precise public numerical code for the unpolarized and polarized massive Wilson coefficients in the asymptotic region.

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