We study the fully nonlocal semilinear equation , , where stands for the Caputo derivative of order and , , is the usual power of the Laplacian. We prescribe an initial datum in . We give conditions ensuring the existence and uniqueness of a solution living in up to a maximal existence time that may be finite or infinite. If~ is finite, the norm of the solution becomes unbounded as time approaches , and is said to blow up in . Otherwise, the solution is global in time. For the case of nonnegative and nontrivial solutions, we give conditions on the initial datum that ensure either blow-up or global existence. It turns out that every nonnegative nontrivial solution in blows up in finite time if whereas if there are both solutions that blow up and global ones. The critical exponent , which does not depend on , coincides with the Fujita exponent for the case , in which the time derivative is the standard (local) one. In contrast to the case , when the critical exponent falls within the situation in which global existence may occur. Our weakest condition for global existence and our condition for blow-up are both related to the size of the mean value of the initial datum in large balls.

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