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Let be a locally finite connected graph. We develop the first eigenvalue method on introduced in 1963 by Kaplan \cite{Kaplan} on Euclidean space, the discrete Phragmén-Lindelöf principle of parabolic equations and upper and lower solutions method on . Using these methods, we establish the estimates and asymptotic behaviour of the life span of solutions to a semilinear heat equation with initial data for different scales of on under some different conditions. Our results are different from the continuous case, which is related to the structure of the graph .

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