We determine cross sections and astrophysical S-factors of the reactions generated in collisions between Li and H, and Li and He. A microscopic three-cluster model is employed to study the dynamics of reactions occurring in the mirror nuclei Be and B. In a previous study [Phys. Rev. C {\bf 109}, 045803 (2024)], this model was successfully applied to investigate the resonance structure of Be and B, as well as reactions induced by the interaction of deuterons with Li and Be. A fairly good agreement between theoretical results and available experimental data was achieved. To the best of our knowledge, appropriate experimental data for the astrophysical S-factors of the reactions generated by the interaction of Li with H and with He are currently unavailable. Thus, our results can serve as a guideline for future experimental efforts.

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